By Geoffrey Burnstock Ph.D., D.Sc., F.A.A., Marcello Costa (auth.)

ISBN-10: 0412140608

ISBN-13: 9780412140600

ISBN-10: 1489972625

ISBN-13: 9781489972620

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Accumulation of granular vesicles and mitochondria has been demonstrated proximal to a ligation in mammalian adrenergic nerves in vivo and in vitro (Kapeller & Mayor, 1967, 1969a; Banks, Mangnal & Mayor, 1969; Geffen & Ostberg, 1969; Hokfelt & Dahlstrom, 1971; Banks & Mayor, 1972). The rate of accumulation ofNA (Hiirkonen, 1964; Dahlstrom, 1965; Dahlstrom & Hiiggendal, 1966b; Dahlstrom, 1971; Livett, Geffen & Austin, 1968), which is closely related to the accumulation of granular vesicles (Banks, Mangnal & Mayor, 1969; Kappeller & Mayor, 1969a; Lever, Spriggs & Graham, 1968), is similar to that of D,BH (Laduron & Belpaire, 1968a, b; Geffen, Hunter & Rush, 1969) and chromagranin A (Geffen, Hunter & Rush, 1969), and corresponds to the fast component of axoplasmic flow.

The rate of transport of acetylcholinesterase (AChE) along cholinergic nerves was also unaffected by electrical stimulation (Jankowska, Lubinska & Niemierko, 1969). 1) and increase the number of vesicles, which are then transported to the terminals (Dahlstrom & Haggendiil, 1969). There is considerable interest in the mechanism of axonal transport (see Dahlstrom, 1971; Mayor, Banks, Tomlinson & Grigas, 1971). Local injections of vinblastine and colchicine in peripheral nerves block the transport of NA granules (Dahlstrom, 1968; Hokfelt & Dahlstrom, 1971).

However, retrograde flow of DA in unligated central dopaminergic neurons in the nigroneostriatal system has been reported (Ungerstedt, Butcher, Butcher, Anden & Fuxe, 1969). Mitochondria and associated enzymes, including MAO (see McLean & Burnstock, 1972), appear to move in both directions, at least after ligation, at a rate of transport of about o·6 mm h - l (Banks, Mangnal & Mayor, 1969). 32 STRUCTURE OF ADRENERGIC NEURONS AND RELATED CELLS Studies by Dahlstrom and her collaborators (see Dahlstrom, 1971) suggest that as adrenergic vesicles are transported down the axon, there is an increase of their NA content.

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Adrenergic Neurons: Their Organization, Function and Development in the Peripheral Nervous System by Geoffrey Burnstock Ph.D., D.Sc., F.A.A., Marcello Costa (auth.)

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