By N. Purdie, Harry G. Brittain

ISBN-10: 0080875629

ISBN-13: 9780080875620

ISBN-10: 0444895086

ISBN-13: 9780444895080

Positive factors specific elements of round dichroism and examines the way it will be of tips to employees within the box. The textual content discusses the actual phenomena linked to dissymmetric compounds which offer upward thrust to the round dichroism influence, and studies the instrumentation on hand.

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Example text

Certainly this time regime can not be accessed by simple modification of conventional CD detection strategies and new approaches have therefore been devised to extend CD measurements into the microsecond, and below, time domain. The crux of this section will be to consider CD detection strategies which are designed to improve the measurement SNR, and therefore allow extension into new domains such as time-resolved CD studies. 1. Fluorescence-DetectedCD Fluorescence detection of CD (FDCD) has been used to extend both the sensitivity and selectivity of the CD experiment [27].

1. As described previously, a high intensity light source in combination with a monochromator provides the monochromatic source light. This light is then plane polarized by a Rochon polarizer which splits the beam spatially into its two orthogonally polarized linear components. One of these components is blocked from the optical path while the other passes through a Pockels cell and into the sample. A phototube is used to monitor the light levels exiting the sample. The Pockels cell is designed to provide a variable phase retardation depending upon the applied voltage.

The inherent limitation of using an incoherent source for the CD system is that conventional incoherent sources can not be molded to efficiently fit within the small dimensions required for microvolume detection. Thus, one must either sacrifice light throughput with a concomitant decrease in sensitivity, or one must be prepared to tolerate large detection volumes with a concomitant decrease in chromatographic resolution and efficiency. Synavec and Yeung [26] used a laser source to facilitate coupling of CD detection to microvolume HPLC.

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Analytical Applications of Circular Dichroism by N. Purdie, Harry G. Brittain

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