By N.N. Sukhareva-Buell
The look for new manufacturers of biologically lively elements (BAS) opposed to human and animal ailments remains to be a tremendous activity in biology and medication. Experimental paintings has to be conducted good just before desire since it takes an ordinary of ten years to boost a brand new drugs, in addition to overtime to place it out there. examine of the Protozoa kinds a distinct department of biology - protozoology. the normal fields of protozoology are taxonomy, phylogeny, morphology, cytology, evolution, ecology and host parasite-interactions. The Protozoa is the one taxon one of the microscopic organisms, which has now not been repeatedly studied as a resource of BAS. This booklet then is the results of the learn at the undertaking: "Biologically lively ingredients of the Mastigophora (Flagellates)". The study was once conducted on the Laboratory of Antibiotics, division of Microbiology, organic college of Moscow country college. Articles of alternative authors at the subject were regarded as the $64000 a part of this reference ebook. The aim of the reference ebook is to explain medical ways, which bring about acquiring biologically energetic elements from cultures of protozoa; the ebook experiences the ancient historical past in reference to modern improvement of the sector. N.N. Sukhareva ACKNOWLEDGMENTS The study was once played in fruitful cooperation with my examine affiliates (V. Urinyuk, T. Titiova, L. Udalova, R. Zeleneva, V. Brusovanik, M. Zaretskaya), postgraduate scholars (N. Kalenik, M. Chuenkova, V. Vasilevskaya, V. Khorokhorina), my colleagues at Moscow nation collage (Yu. Kozlov and I.
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Extra info for Biologically Active Substances of Protozoa
Inositol acylation of lipids is a chemically important step in OPI biosynthesis. Results suggest that inositol acylation occurs after the formation of OleN-PI, but before the addition of mannose . Inositol acylated lipids may be more appropriate substrates for glycosyltransferases than their non-inositol-acylated counterparts. Additional fatty acids can be added only after the formation of dimannophosphoinositide. Hyperacylation may be an essential reaction for continued mannosylation (Menon , 1991).
1982; Sukhareva, 1989). Saturated fatty acids are represented by C I2 :0 , C I4 :0• C 15 :0, C I6:0 , and C I8:0 . 1). Similar results were obtained in amastigotes and trypomastigotes of T. , 1989). A similar tendency of C l 6 and C I8 unsaturated fatty acids to have prevalence has been observed in lipids of T. , 1980, 1981). Fatty acids from the total lipid fraction of A. , 1983) .. A. 2). 3). Unsaturated compounds (64-68 % of total fatty acid content) are represented by the following fatty acids and their isomers : C 18: 1 (8 or 9 or 10 or II or 12), C 18:2 (9, 12 or 11,14), C20 :3(5 , 10, 130r 8, 11, 13),C 2o :4(5 , 8, 11, 14 or 8,11 ,14,17), docosapentaenoate C 22:5 (4, 7, 10, 13, 16), and C22 :6 (5, 8, 11, 14, 17,20).
This pathway starts with the acylation of DHAP acyltransferase. The product of this reaction , acyl-DHAP , is then converted to alkyl-DHAP by alkyl-DHAP synthase; and finally, acyl/alkyl DHAP reductase catalyses the reduction of alkyl DHAP and acyl-DHAP into l- alkyl glycerol -3-phosphate or l-acyl glycerol -3 phosphate . , 1995). There is another pathway, the glycerol3-phosphate (G3P) pathway that is typical for strictly anaerobi c rumen protozoa and bacteria. It is not associated with glycosomes, but rather with methanogenic endo symbionts..
Biologically Active Substances of Protozoa by N.N. Sukhareva-Buell