By William Bialek

ISBN-10: 0691138915

ISBN-13: 9780691138916

Interactions among the fields of physics and biology achieve again over a century, and a few of the main major advancements in biology--from the invention of DNA's constitution to imaging of the human brain--have concerned collaboration throughout this disciplinary boundary. For a brand new iteration of physicists, the phenomena of existence pose fascinating demanding situations to physics itself, and biophysics has emerged as a tremendous subfield of this self-discipline. the following, William Bialek presents the 1st graduate-level creation to biophysics geared toward physics scholars.

Bialek starts by means of exploring how photon counting in imaginative and prescient bargains very important classes in regards to the possibilities for quantitative, physics-style experiments on assorted organic phenomena. He attracts from those classes 3 basic actual principles--the value of noise, the necessity to comprehend the extreme functionality of residing structures with no beautiful to finely tuned parameters, and the serious position of the illustration and stream of data within the company of lifestyles. Bialek then applies those ideas to a huge variety of phenomena, together with the regulate of gene expression, conception and reminiscence, protein folding, the mechanics of the interior ear, the dynamics of biochemical reactions, and development formation in constructing embryos.

Featuring a variety of difficulties and workouts all through, Biophysics emphasizes the unifying strength of summary actual rules to encourage new and novel experiments on organic structures.

  • Covers a number organic phenomena from the physicist's point of view
  • Features two hundred difficulties
  • Draws on statistical mechanics, quantum mechanics, and comparable mathematical techniques
  • Includes an annotated bibliography and specific appendixes
  • Instructor's handbook (available merely to academics)

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Extra info for Biophysics: Searching for Principles

Sample text

The current that flows across the membrane has to go somewhere, and the circuit is completed within the rod cell itself, so that what flows across the outer segment of the cell is compensated by flow across the inner segment. When the rod cell is exposed to light, the standing current is reduced, and with sufficiently bright flashes it is turned off all together. As in any circuit, current flow generates changes in the voltage across the cell membrane. Near the bottom of the cell there are special channels that allow calcium ions to flow into the cell in response to these voltage changes, and calcium in turn triggers the fusion of vesicles with the cell membrane.

D) Put all these steps together to show that the coherent state is a minimum uncertainty wave packet with expected values of the position and momentum that follow the classical equations of motion. The states of light inside a laser are, to a good approximation, coherent states. Thus, they are minimum uncertainty states and hence push against the limits of what is allowed by quantum mechanics, but at the same time they are very classical states, because they are described by the same parameters as a classical light field.

So, Aho et al. convinced toads to strike with their tongues at small wormlike objects illuminated by very dim lights, as shown in Fig. 7. Because one can actually 6. It is perhaps too much to go through all these results here, beautiful as they are. To explore, see the references for this section in the Annotated Bibliography. 7. The sign of the prediction is important. If we were looking for more reliable behaviors at higher temperatures, there could be many reasons for this, such as quicker responses of the muscles.

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Biophysics: Searching for Principles by William Bialek


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