By John N. Abelson, Melvin I. Simon, Helmut Sies

ISBN-10: 0121821536

ISBN-13: 9780121821531

The seriously acclaimed laboratory common for 40 years, equipment in Enzymology is likely one of the so much hugely revered courses within the box of biochemistry. considering that 1955, every one quantity has been eagerlyawaited, usually consulted, and praised by way of researchers and reviewers alike. greater than 250 volumes were released (all of them nonetheless in print) and masses of the fabric is appropriate even today--truly a vital e-book for researchers in all fields of lifestyles sciences. Key good points* Distribution, biosynthesis, metabolism, and delivery of glutathione* sign transduction and gene law* Thioredoxin and glutaredoxin* Mimics of organic thiols and thiol inhibitors

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Additional resources for Biothiols, Part B: Glutathione and Thioredoxin: Thiols in Signal Transduction and Gene Regulation

Example text

Bjelland, B. Foltmann, and K. Wallevik, Anal. Biochem. 142, 463 (1984). ~ GSSG E-S- \SH (OH) FIG. 1. Proposed scheme for the DHA reductase mechanism of thioltransferase. Reaction of the nucleophilicCys-22leads to a thiohemiketal intermediate. The reduced product, ascorbic acid (AA), is displaced by glutathione in the active mutant C25S to form a mixed disulfide that is further displaced by GSH to form GSSG and reduced enzyme. Alternatively, an intramolecular disulfide pathway can displace the reduction product, ascorbic acid, followed by exchange with 2 mol of GSH successively.

Maellaro, B. Del Bello, L. Sugherini, A. Santucci, M. Comporti, and A. F. Casini, Biochem. J. 301, 471 (1994). [51 D i v e r s i t y o f G l u t a t h i o n e By F. Peroxidases URSINI,M. MAIORINO,R. BRIGELIuS-FLoHI~,K. D. AUMANN, A. ROVERI, D. SCHOMBURG,and L. FLOHE Introduction Selenium was identified as a toxic factor for grazing animals in the first half of the twentieth century and since then has been considered hazardous. , 1976. 252 Copyright© 1995by AcademicPress,Inc. All rightsof reproductionin any formreserved.

Akasaka, Y. Yamamoto, C. Kobayashi, J. Mizoguchi, and J. Koyama, J. Biochem. (Tokyo) 108, 145 (1990). 35 j. M. Martin-Alonso, S. Gosh, and M. Coca-Prados, J. Biochem. (Tokyo) 114, 284 (1993). 36 H. Hatta and T. Moriuchi, Biochem. J. 109, 918 (1991). 37 A. C. Perry, R. Jones, L. S. Niang, R. M. Jackson, and L. Hall, Biochem. J. 285, 863 (1992). 38 N. B. -P. Dufaure, Nucleic Acids Res. 18, 7144 (1990). 39 T. N. Dear, K. Campbell, and T. H. Rabbitts, Biochemistry 30, 10376 (1991). 40 M. J. Friedrich, L.

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Biothiols, Part B: Glutathione and Thioredoxin: Thiols in Signal Transduction and Gene Regulation by John N. Abelson, Melvin I. Simon, Helmut Sies


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