By Gerhardus de Jong
This monograph deals the reader a whole evaluate on either rules and purposes of CE-MS. beginning with an introductory bankruptcy on detection in CE, additionally comparable and extra really expert ideas corresponding to electrophoretic and chromatographic preconcentration are mentioned. a distinct emphasis is wear CE-MS interfaces, that are defined intimately. In a separate bankruptcy, recognition is paid to sheath-liquid interfacing. The advancements and probabilities of microchip CE-MS also are defined. functions to all proper parts are mentioned in distinctive chapters, each one written via specialists within the respective fields.
along with functions in pharmaceutical research and bioanalysis, contemporary implementations in nutrition technology, forensic research, research of intact proteins, metabolomics and proteomics are highlighted. MS is a wonderfully acceptable detection process for CE, as effective separation is coupled to delicate and choice detection. in addition, MS supplies constitution info at the separated compounds. CE-MS has now been built right into a robust hyphenated procedure complementary to LC-MS. This monograph is an particular resource of data for everybody facing and drawn to CE-MS
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Extra resources for Capillary Electrophoresis - Mass Spectrometry (CE-MS) Principles and Applications
2011) Dating silk by capillary electrophoresis mass spectrometry. Anal. , 83, 7577–7581. 39 41 3 Sheath Liquids in CE-MS: Role, Parameters, and Optimization Christian W. 1 Introduction Only 6 years after the ﬁrst paper on capillary electrophoresis (CE) by Jorgenson and Lukacs in 1981 , Smith’s group described the coupling of CE with mass spectrometric detection (MS), using an interface without a sheath ﬂow . Just 1 year later, the same group presented an improved electrospray ionization (ESI) interface for CE-MS, this time involving the use of a sheath liquid (SL) .
85. 86. proﬁling of intact pharmaceutical proteins. Anal. , 85, 2289–2296. Y. (2012) Monitoring potential prostate cancer biomarkers in urine by capillary electrophoresis–tandem mass spectrometry. J. Chromatogr. A, 1267, 162–169. , and Li, L. (2015) Relative quantiﬁcation of amine-containing metabolites using isobaric N,N-dimethyl leucine (DiLeu) reagents via LC-ESI-MS/MS and CE-ESI-MS/MS. Analyst, 140, 467–475. , and Hankemeier, T. (2014) Capillary electrophoresis–mass spectrometry using a ﬂow-through microvial interface for cationic metabolome analysis.
2010) Mass spectrometry and glycomics. OMICS, 14, 401–418. M. et al. (2013) Coupling porous sheathless interface MS with transient-ITP in neutral capillaries for improved sensitivity in glycopeptide analysis: CE and CEC. Electrophoresis, 34, 383–387. W. (2013) Low-ﬂow sheathless capillary electrophoresis–mass spectrometry for sensitive glycoform References 79. 80. 81. 82. 83. 84. 85. 86. proﬁling of intact pharmaceutical proteins. Anal. , 85, 2289–2296. Y. (2012) Monitoring potential prostate cancer biomarkers in urine by capillary electrophoresis–tandem mass spectrometry.
Capillary Electrophoresis - Mass Spectrometry (CE-MS) Principles and Applications by Gerhardus de Jong