By Richard Bucala
Because the discovery of the circulating fibrocyte in 1994 as a collagen-producing cellphone of the peripheral blood, the physiologic and pathologic function of this precise phone populaton has grown gradually. This pioneering new booklet presents the 1st finished evaluate of the position of fibrocytes in wound fix, granuloma formation, antigen presentation, scar formation, and diverse fibrosing problems reminiscent of interstitial lung illness and nephrogenic systemic fibrosis. additionally it is discussions of the hot reports at the molecular indications that impact fibrocyte migration, proliferation, and serve as within the context of standard body structure and pathology. The chapters are contributed through the major researchers within the box.
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Additional resources for Fibrocytes: New Insights into Tissue Repair And Systemic Fibrosis
20. Pilling D, Buckley CD, Salmon M, Gomer RH. (2003) Inhibition of ﬁbrocyte differentiation by serum amyloid P. J Immunol 171: 5537–5546. 21. Yang LJ, Scott PG, Giuffre J, et al. (2002) Peripheral blood ﬁbrocytes from burn patients: identiﬁcation and quantiﬁcation of ﬁbrocytes in adherent cells cultured from peripheral blood mononuclear cells. Lab Invest 82: 1183–1192. 22. Labat ML, Bringuier AF, Arysphilippart C, et al. (1994) Monocytic origin of ﬁbrosis — in vitro transformation of Hla-Dr monocytes into neoﬁbroblasts — inhibitory effect of all-trans-retinoic acid on this process.
2006). ch01 FA October 6, 2006 6:24 14 WSPC/SPI-B408: Fibrocytes: New Insights into Tissue Repair and Systemic Fibroses R. Bucala IL-1, SLC, CXCL12, and serum amyloid P inﬂuence ﬁbrocyte function, proliferative potential, differentiation into myoﬁbroblasts, and trafﬁcking properties. Whether the circulating ﬁbrocyte explains the origin of the myoﬁbroblast, which features prominently in many pathologic ﬁbroses, is of interest in better understanding many chronic diseases. This model of ﬁbrocyte action does not discount the important role of locally-derived, connective tissue cells in the host response but suggests that the contribution of circulating ﬁbrocytes to a particular site of injury likely reﬂects the inﬂammatory character of the lesion and the relative abundance of ﬁbrocytes, which may enter from exudative ﬂuid, versus local connective tissue sources of ﬁbroblasts.
39. Chauhan H, Abraham A, Phillips JRA, et al. (2003) There is more than one kind of myoﬁbroblast: analysis of CD34 expression in benign, in situ, and invasive breast lesions. J Clin Pathol 56: 271–276. 40. Ramaswamy A, Moll R, Barth PJ. (2003) CD34+ ﬁbrocytes in tubular carcinomas and radial scars of the breast. Virchows Archiv 443: 536–540. 41. Kirchmann TTT, Prieto VG, Smoller BR. (1994) CD34 staining pattern distinguishes basal-cell carcinoma from trichoepithelioma. Arch Dermatol 130: 589–592.
Fibrocytes: New Insights into Tissue Repair And Systemic Fibrosis by Richard Bucala