By S. Gordon, S. Hirsch, P. Starkey (auth.), Ralph van Furth (eds.)

ISBN-10: 9400950209

ISBN-13: 9789400950207

ISBN-10: 9401087237

ISBN-13: 9789401087230

Sixteen years have handed because the first Leiden convention on Mononuclear Phagocytes. That first assembly resulted in new nomenclature, i. e. , the Mononuclear Phagocytes process (MPS), which used to be released within the Bulletin of the area future health association (R. van Furth, et aI. , Bull. WHO, 1972, forty six: 845-852). The paradigm of the MPS has the good thing about being even more constant than the Reticuloendothelial approach (RES) (L. Aschoff, Ergebn. hotel. Med. Kinderheilk. 1924, 26:1), simply because cells with related features might be labeled within the similar class. The essence ota new idea is, based on Popper, that it has to be liable to falsification. This has been tried numerous occasions for the MPS through those that adhere to the RES. besides the fact that, in biology nobody will be yes of fact. Any conception has to be in response to experimental observations and/or theoretical give some thought to­ ations and either can be offered in this kind of means that others can attempt to refute it, then or later. One could have a theoretical or a realistic choice for a concept which at a given time is considered very likely truc, yet later it can be proven to be fake. In different phrases, what we found in this quantity is considered real at this second, yet others could give some thought to it as now not real and take a look at to disprove it. Controversies frequently stimulate new research.

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3. Daems WT, De Bakker JM: Do resident macrophages proliferate? Immunobiol 1982, 161:204-211. 4. Miller GA, Morahan PS. White S, Jessee E: Functional and 16 5. 6. 7. 8. 9. 10. 11. 12. 13. 14. 15. 16. 17. 18. 19. biochemical heterogeneity among subpopulations of rat and mouse peritoneal macrophages. J Reticuloendothel Soc 1982, 32:111-124. Haskill S, Becker S: Flow cytometric analysis of macrophage heterogeneity and differentiation - Utilisation of electronic cell volume and fluorescent substrates corresponding to common macrophage markers.

Baldwin F: Microglia and brain macrophages. In: The Reticuloendothelial System - A Comprehensive Treatise. Vol. 1. Morphology. , Daems NT Eds. Y. 1981, pp 635-670. Oehmichen M: Are resting andlor reactive microglia macrophages? Immunobiol1982, 161:246-254. Hume DA, Perry VH, Gordon S: Immunohistochemical localisation of macrophage-specific antigen in developing mouse retina: Phagocytosis of dying neurons and differentiation of microglial cells to form a regular array in the plexiform layers. J Cell Bioi 1983, 97:253-257.

Eur J Immunol1979, 9:301-306. McMaster WR, Williams AF: Identification of Ia glycopro- teins in rat thymus and purification from rat spleen. Eur J ImmunoI1979,9:426-433. 22. Robbins 0, Fahimi HO, Cot ran RS: Fine structural cytochemical localization of peroxidase activity in rat peritoneal cells: mononuclear cells, eosinophils and mast cells. J Histochem Cytochem 1971, 19:571-575. 23. Beelen RHJ, Broekhuis-Fluitsma OM, Korn C, Hoefsmit ECM: Identification of exudate-resident macrophages on the basis of peroxidatic activity.

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Mononuclear Phagocytes: Characteristics, Physiology and Function by S. Gordon, S. Hirsch, P. Starkey (auth.), Ralph van Furth (eds.)


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