By Aixa Alfonso, Gregory S. Payne, Julie Donaldson, Nava Segev

ISBN-10: 0387938761

ISBN-13: 9780387938769

This booklet covers the previous, current and way forward for the intra-cellular trafficking box, which has made a quantum bounce within the previous few many years. It info how the sector has constructed and advanced in addition to examines destiny directions.

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Extra resources for Trafficking Inside Cells: Pathways, Mechanisms and Regulation (Molecular Biology Intelligence Unit)

Example text

5C). A foreseeable problem with haploid yeast is that mutations in essential genes, such as those required for secretion, will be lethal. As a consequence, most ofthe genetic screens for transport mutants were designed to select for temperature-sensitive (ts) mutations. Temperature sensitivity usually arises from a single amino acid change (a missense mutation) that destabilizes the functional conformation ofa protein, and renders the protein susceptible to thermally-induced shifts from active to inactive conformation.

The most common ts phenotype is heat sensitivity. These mutants exhibit a nearly wild type (we) growth phenotype at a low permissive temperature (20-30 °C), and a mutant phenotype at higher, nonpermissive temperatures (30-3TC). 26 Trafficking Inside Cells: Pathways, Mechanisms andRegulation B. Complementary Alellic (0) (a) Mating 1 (a) (a) + XI Mating '6Y. Xy C. (0) (a) xV + Xy Dominant + 1 MBOOg I XV 1 V (alu ) ~v (ala) (ala) wt ts ts Haploid xV MBting + 1 Xy Xy -: Spores Haploid Diploid Figure 5.

28 Trafficking Inside Cells: Pathways, Mechanisms andRegulation The majority of mutants with defects in transport per se tend to accumulate distended organelles that lie just proximal to the blocked transport step. 107,119 When the block affects the targeting or fusion of transport intermediates derived from the distended organelle, vesicles may also accumulate. 116 As might be expected for an organelle at the end of a branched pathway, mutants that are defective in vacuolar transport, biogenesis or inheritance often exhibit fragmented or unidentifiable vacuoles.

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Trafficking Inside Cells: Pathways, Mechanisms and Regulation (Molecular Biology Intelligence Unit) by Aixa Alfonso, Gregory S. Payne, Julie Donaldson, Nava Segev


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